Types of Ehlers-Danlos Syndrome

A directory of the 12 rare and ultra-rare forms of EDS. Select a type to open its dedicated page with detailed symptoms, genetics, inheritance, and photos.

The 12 genetically defined types of Ehlers-Danlos Syndrome

Arthrochalasia EDS

aEDS

COL1A1 or COL1A2

Born with hip dislocations and very loose, fragile joints.

Autosomal dominant Explore aEDS

Brittle Cornea Syndrome

BCS

ZNF469 or PRDM5

A thin, fragile cornea with a high risk of eye injury.

Autosomal recessive Explore BCS

Cardiac-Valvular EDS

cvEDS

COL1A2

Progressive heart-valve disease with fragile, stretchy skin.

Autosomal recessive Explore cvEDS

Classical EDS

cEDS

COL5A1, COL5A2, or COL1A1

Very stretchy skin, easy scarring, and hypermobile joints.

Autosomal dominant Explore cEDS

Classical-Like EDS

clEDS

TNXB or AEBP1

Soft, stretchy skin and loose joints, without atrophic scarring.

Autosomal recessive Explore clEDS

Dermatosparaxis EDS

dEDS

ADAMTS2

Extremely fragile, sagging skin that bruises and tears easily.

Autosomal recessive Explore dEDS

Kyphoscoliotic EDS

kEDS

PLOD1 or FKBP14

Severe spinal curvature from birth with low muscle tone.

Autosomal recessive Explore kEDS

Musculocontractural EDS

mcEDS

CHST14 or DSE

Multiple joint contractures present from birth, with distinctive features.

Autosomal recessive Explore mcEDS

Myopathic EDS

mEDS

COL12A1

Muscle weakness in childhood alongside loose distal joints.

Autosomal dominant or recessive Explore mEDS

Periodontal EDS

pEDS

C1R or C1S

Severe early gum disease and tooth loss with fragile skin.

Autosomal dominant Explore pEDS

Spondylodysplastic EDS

spEDS

B4GALT7, B3GALT6, or SLC39A13

Short stature with skeletal differences and loose joints.

Autosomal recessive Explore spEDS

Vascular EDS

vEDS

COL3A1 or COL1A1

Fragile blood vessels and hollow organs that can rupture.

Autosomal dominant Explore vEDS

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